Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Accepted Preprint first posted online on 1 May 2008

European Journal of Endocrinology 2008;159:R1.

DOI: 10.1530/EJE-08-0212
Copyright © 2008 by European Society of Endocrinology
This Article
Right arrow Accepted manuscript (PDF)
Right arrow All Versions of this Article:
EJE-08-0212v1
159/1/R1    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soriano-guillen, L.
Right arrow Articles by Rovira, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soriano-guillen, L.
Right arrow Articles by Rovira, A.
RESEARCH

HIGH SENSITIVITY C REACTIVE PROTEIN IS A GOOD MARKER OF CARDIOVASCULAR RISK FACTOR IN OBESE CHILDREN AND ADOLESCENTS

Leandro Soriano-guillen, Barbara Hernandez-garcia, Jimena Pita, Nieves Dominguez-garrido, Genoveva Del Rio-camacho and Adela Rovira

L Soriano-guillen, PEDIATRICS, FUNDACION JIMENEZ DIAZ, MADRID, MADRID, Spain
B Hernandez-garcia, PEDIATRICS, FUNDACION JIMENEZ DIAZ, MADRID, Spain
J Pita, LABORATORY OF ENDOCRINOLOGY, FUNDACION JIMENEZ DIAZ, MADRID, Spain
N Dominguez-garrido, PEDIATRICS, FUNDACION JIMENEZ DIAZ, MADRID, Spain
G Del Rio-camacho, PEDIATRICS, FUNDACION JIMENEZ DIAZ, MADRID, Spain
A Rovira, ENDOCRINOLOGY, FUNDACION JIMENEZ DIAZ, MADRID, Spain

Correspondence: Leandro Soriano-guillen, Email: leansor4{at}hotmail.com

Abstract

Objective: We intend to assess the utility of the high-sensitivity c-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.

Methods: The study included children and adolescents between 6 and 18 years old with a body mass index BMI higher than 2 SDS. All the patients had their blood pressure taken and high-sensitivity c-reactive protein, hepatic function, lipid profile and uric acid were determined after 12 hours of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased HDL-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.

Results: Of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/L; 95% CI: 2.8-4.8) in comparison with obese patients who did not show signs of metabolic syndrome (mean: 2 mg/L; 95% CI: 1.5-2.5). After a multivariate analysis, the variables that appear to influence the changes of hs-CRP were BMI, triglycerides and HDL-cholesterol levels.

Conclusion: The hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2008 European Society of Endocrinology.