HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Accepted manuscript (PDF) All Versions of this Article: EJE-08-0097v1 159/2/121    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vrbikova, J. Articles by Pacini, G. Search for Related Content PubMed PubMed Citation Articles by Vrbikova, J. Articles by Pacini, G.

Incretin levels in polycystic ovary syndrome

J Vrbikova, Clinical Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
M Hill, Department of steroid hormones, Institute of Endocrinology, Prague, Czech Republic
B Bendlova, Molecular Endocrinology, Institute of Endocrinology, Prague 1, Czech Republic
T Grimmichova, Department of Functional Diagnostics, Institute of Endocrinology, Prague 1, United Kingdom
K Dvorakova, Clinical Endocrinology, Institute of Endocrinology, Praha 1, 116 94, Czech Republic
K Vondra, Department of Functional Diagnostics, Institute of Endocrinology, Prague 1, United Kingdom
G Pacini, Metabolic Unit, Institute of Biomedical Engineering, National Research Council,, Padova, Italy

Correspondence: Katerina Dvorakova, Email: kdvorakova{at}endo.cz

Abstract

Objective: Polycystic ovary syndrome (PCOS) is linked to a high risk of type 2 diabetes mellitus (T2DM). Disturbances in the secretion of glucose dependent insulinotropic polypeptide (GIP) and glucagon like peptide 1 (GLP 1) have been observed in states with impaired glucose regulation. Design: Case control.Methods: PCOS (n=21, 25.8±4.1 years, BMI 21.6±1.7 kg/m2) and control healthy women (CT, n=13, 28.5±7.2 years, BMI 20.3±2.5 kg/m 2) underwent OGTT with blood sampling for glucose, insulin, C peptide, total GIP and active GLP 1. Insulin sensitivity was determined both at fasting and during the test.Statistics: Repeated measures ANOVA.Results: Glucose levels and insulin sensitivity did not differ between PCOS and CT. PCOS had significantly higher levels of C peptide (p0.05), and tended to have higher insulin levels. The levels of total GIP were significantly higher in PCOS than in CT (p0.001). Active GLP 1 levels exhibited a significantly different time dependent pattern in PCOS (p0.008 for PCOS vs. time interaction). GLP 1 concentrations were similar in PCOS and CT in the early phase of OGTT and then reached significantly lower levels in PCOS than in CT at 180 mins (p0.05).

Conclusions: Increased total GIP and lower late phase active GLP 1 concentrations during OGTT characterize PCOS women with higher C peptide secretion in comparison to healthy controls, and may be the early markers of a pre diabetic state.