Eur J Endocrinol
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DOI: 10.1530/eje.1.02328
European Journal of Endocrinology, Vol 156, Issue 2, 257-261
Copyright © 2007 by European Society of Endocrinology
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CLINICAL STUDY

Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans

Susan Kralisch, Matthias Bluher, Anke Tonjes, Ulrike Lossner, Ralf Paschke, Michael Stumvoll and Mathias Fasshauer

Department of Internal Medicine III, University of Leipzig, Ph.-Rosenthal-Str. 27, 04103 Leipzig, Germany

(Correspondence should be addressed to M Fasshauer; Email: mathias.fasshauer{at}medizin.uni-leipzig.de)

Objective: Tissue inhibitor of metalloproteinase (TIMP)-1 is upregulated in fat of obese rodents and promotes adipose tissue development in these animals. However, it is unclear whether TIMP-1 independently predicts adiposity in humans and whether serum levels are increased in s.c. and visceral obesity.

Design: Twenty-four lean, 16 s.c. obese, and 20 visceral obese subjects were studied.

Methods: Plasma TIMP-1 concentrations were quantified using ELISAs and correlated to clinical parameters.

Results: Plasma TIMP-1 levels were significantly different between lean (156 ± 42 µg/l), s.c. obese (186 ± 52 µg/l), and visceral obese (198 ± 42 µg/l) subjects (P < 0.01). Furthermore, TIMP-1 correlated positively with body mass index (BMI), waist-to-hip ratio (WHR), % body fat, fasting insulin, free fatty acids, cholesterol, leptin, interleukin-6, and negatively with adiponectin (P < 0.05). Moreover, TIMP-1 serum levels predicted % body fat but not WHR independent of age, sex, and plasma insulin.

Conclusions: We demonstrate that increased TIMP-1 serum levels are found with increased adiposity in humans.




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