HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kowalska, I. Articles by Górska, M. Search for Related Content PubMed PubMed Citation Articles by Kowalska, I. Articles by Górska, M.

Plasma adiponectin concentration and tumor necrosis factor- system activity in lean non-diabetic offspring of type 2 diabetic subjects

Irina Kowalska, Marek Strczkowski, Agnieszka Nikolajuk, Agnieszka Krukowska, Ida Kinalska and Maria Górska

Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15276 Bialystok, ul. M C Sklodowskiej 24a, Poland

(Correspondence should be addressed to I Kowalska; Email:irinak{at}poczta.onet.pl)

Objective: There is growing evidence that adiponectin function is related to the pathogenesis of insulin resistance. Insulin resistance might be present even in lean subjects with a strong family history of type 2 diabetes. The aim of the study was to look for adiponectin’s role in the pathogenesis of insulin resistance in offspring of type 2 diabetic patients, and its relation to the activity of the tumor necrosis factor (TNF)- system.

Research design and methods: The study was carried out in 23 lean offspring of type 2 diabetic subjects and in 23 controls matched for age, sex and body mass index. The oral glucose tolerance test for glucose and insulin estimations and hyperinsulinemic, euglycemic clamp studies were performed in all patients. The plasma concentration of adiponectin, TNF-, soluble TNF receptors 1 and 2 (sTNFR1, sTNFR2), HbA1c, total cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein-cholesterol and triglycerides were estimated.

Results: The insulin sensitivity index, normalized for fat-free mass (M_ffm) and adiponectin concentrations were markedly decreased in offspring of type 2 diabetic subjects compared with the control group (P = 0.0046 and P = 0.00 058 respectively). TNF- and sTNFR1 concentrations did not differ between the studied groups; however the concentration of sTNFR2 was markedly increased in the offspring of type 2 diabetic patients (P = 0.0002). Adiponectin concentration was positively correlated to the insulin sensitivity index (r = 0.34; P = 0.020) and to HDL-cholesterol (r = 0.29, P = 0.047) and was inversely related to sTNFR2 (r = –0.33, P = 0.027).

Conclusions: The obtained results suggest that adiponectin could play a role in the pathogenesis of insulin resistance in lean offspring of type 2 diabetic subjects.

This article has been cited by other articles:

				M. Karczewska-Kupczewska, M. Straczkowski, A. Adamska, A. Nikolajuk, E. Otziomek, M. Gorska, and I. Kowalska Increased suppression of serum ghrelin concentration by hyperinsulinemia in women with anorexia nervosa Eur. J. Endocrinol., February 1, 2010; 162(2): 235 - 239. [Abstract] [Full Text] [PDF]

				J. W. Sull, H. J. Kim, J. E. Yun, G. Kim, E. J. Park, S. Kim, H. Y. Lee, and S. H. Jee Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women Eur. J. Endocrinol., January 1, 2009; 160(1): 39 - 43. [Abstract] [Full Text] [PDF]