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Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects

Department of Internal Medicine, Division of Diabetology and Endocrinology, ¹ Division of Pulmonary and Critical Care Medicine, ² Department of Radiology and ³ Department of Laboratory Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507 Japan and ⁴ Department of Health and Physical Education, Mie University Faculty of Education, Mie,Japan

(Correspondence should be addressed to Y Sumida: Email: sumidaya{at}clin.medic.mie-u.ac.jp)

Objective: To investigate the relationship between active ghrelin and oxidative stress in obese subjects.

Design: We measured the plasma levels of free 8-epi-prostaglandin F₂ (8-epi-PGF₂, a reliable and systemic marker of oxidative stress) and the active form of ghrelin in 17 obese and 17 normal subjects. The biologically active forms of ghrelin were measured using a commercially available radio-immunoassay kit and free 8-epi-PGF₂ was measured using an enzyme immunoassay kit.

Results: The circulating level of active ghrelin was significantly decreased (20.4 ± 2.6 vs 40.9 ± 3.9 fmol/ml, P < 0.01) while that of 8-epi-PGF₂ was significantly increased (61.5 ± 9.6 vs 17.3 ± 3.4 pg/ml, P < 0.01) in obese subjects compared with normal subjects. The plasma levels of active ghrelin and 8-epi-PGF₂ were significantly correlated in obese (r = –0.507, P < 0.05) and in all (r = –0.577, P < 0.01) subjects. Multivariate analysis showed that the plasma levels of active ghrelin and 8-epi-PGF₂ were significantly and independently correlated in all subjects (F = 7.888, P < 0.01).

Conclusions: There is an inverse correlation between circulating levels of active ghrelin and oxidative stress in obesity. Low circulating levels of active ghrelin may enhance oxidative stress and the process of atherosclerosis in obese subjects.

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