| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CLINICAL STUDY |
Department of Clinical Medicine, University of Palermo, Palermo, Italy, 1 Department of Oncology and Molecular Endocrinology, Federico II University, Naples, Italy, 2 Department of Obstetrics and Gynecology, University Magna Grecia of Catanzaro, Catanzaro, Italy and 3 Department of Obstetrics and Gynecology, Columbia University, New York, New York, USA
(Correspondence should be addressed to R A Lobo, Department of Obstetrics and Gynecology, Columbia-Presbyterian Medical Center, 622 West 168th Street, PH-16, Room 69, New York 10032-3784, USA; Email: ral35{at}columbia.edu)
Background: Adipocytokines are produced by adipose tissue and have been thought to be related to insulin resistance and other health consequences. We measured leptin, adiponectin, and resistin simultaneously in women with polycystic ovary syndrome (PCOS) and age- and weight-matched controls. Our hypothesis was that these simultaneous measurements would help determine whether adipocytokine secretion is abnormal in PCOS independent of body mass and whether these levels are related to insulin resistance as well as other hormonal changes.
Methods: Fifty-two women with PCOS and 45 normal ovulatory women who were age- and weight-matched were studied. Blood was obtained for adipocytokines (leptin, adiponectin, and resistin) as well as hormonal parameters and markers of insulin resistance as assessed by the quantitative insulin-sensitivity check index. Body mass index (BMI) was stratified into obese, overweight, and normal subgroups for comparisons between PCOS and controls.
Results: Adiponectin was lower (P < 0.05) and resistin was higher (P < 0.05) while leptin was similar to matched controls. Breakdown of the groups into subgroups showed a strong body mass relationship for leptin with no changes in resistin although adiponectin was lower in PCOS, even controlling for BMI. In controls, leptin and adiponectin and leptin and resistin correlated (P < 0.05) but not in PCOS. In controls, all adipocytokines correlated with markers of insulin resistance but not in PCOS.
Conclusions: When matched for BMI status, decreased adiponectin in PCOS represent the most marked change. This alteration may be the result of altered adipose tissue distribution and function in PCOS but no correlation with insulin resistance was found.
This article has been cited by other articles:
|
|
 |
|
  A. O'Connor, N. Phelan, T. K. Tun, G. Boran, J. Gibney, and H. M. Roche High-Molecular-Weight Adiponectin Is Selectively Reduced in Women with Polycystic Ovary Syndrome Independent of Body Mass Index and Severity of Insulin Resistance J. Clin. Endocrinol. Metab., March 1, 2010; 95(3): 1378 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.A. Toulis, D.G. Goulis, D. Farmakiotis, N.A. Georgopoulos, I. Katsikis, B.C. Tarlatzis, I. Papadimas, and D. Panidis Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis Hum. Reprod. Update, May 1, 2009; 15(3): 297 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.L. Hendriks, J.C.F. Ket, P.G.A. Hompes, R. Homburg, and C.B. Lambalk Why does ovarian surgery in PCOS help? Insight into the endocrine implications of ovarian surgery for ovulation induction in polycystic ovary syndrome Hum. Reprod. Update, May 1, 2007; 13(3): 249 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Baba, T. Endo, H. Honnma, Y. Kitajima, T. Hayashi, H. Ikeda, N. Masumori, H. Kamiya, O. Moriwaka, and T. Saito Association between polycystic ovary syndrome and female-to-male transsexuality Hum. Reprod., April 1, 2007; 22(4): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Majuri, M Santaniemi, K Rautio, A Kunnari, J Vartiainen, A Ruokonen, Y A Kesaniemi, J S Tapanainen, O Ukkola, and L Morin-Papunen Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study Eur. J. Endocrinol., February 1, 2007; 156(2): 263 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ledoux, D. B. Campos, F. L. Lopes, M. Dobias-Goff, M.-F. Palin, and B. D. Murphy Adiponectin Induces Periovulatory Changes in Ovarian Follicular Cells Endocrinology, November 1, 2006; 147(11): 5178 - 5186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.F. Escobar-Morreale, G. Villuendas, J.I. Botella-Carretero, F. Alvarez-Blasco, R. Sanchon, M. Luque-Ramirez, and J.L. San Millan Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study Hum. Reprod., September 1, 2006; 21(9): 2257 - 2265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Glintborg, M. Andersen, C. Hagen, J. Frystyk, V. Hulstrom, A. Flyvbjerg, and A. P. Hermann Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur. J. Endocrinol., August 1, 2006; 155(2): 337 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Mitchell, D T Armstrong, R L Robker, and R J Norman Adipokines: implications for female fertility and obesity Reproduction, November 1, 2005; 130(5): 583 - 597. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
