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DOI: 10.1530/eje.0.151S067
European Journal of Endocrinology, Vol 151, Suppl_1, S67-S70
Copyright © 2004 by European Society of Endocrinology
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Articles

Ghrelin: update on a novel hormonal system

M Korbonits and AB Grossman

Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE, UK. m.korbonits@qmul.ac.uk

Ghrelin is a peptide hormone secreted into the circulation from the stomach but also synthesised in a number of tissues, suggesting both endocrine and paracrine effects. These include: stimulation of GH, prolactin and ACTH secretion; an increase in appetite; a diabetogenic effect on carbohydrate metabolism; positive inotropic effects on heart; vasodilatation; and effects on cell proliferation. The possibility of chronic manipulation of the ghrelin system on body weight, growth and appetite remains an exciting new field of exploration.


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