| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Articles |
Endocrinology and Metabolism Division, Baskent University, Dadaloglu Mah, Serin Evler 39, Sok. No. 6, 01250 Yuregir, Adana, Turkey.
OBJECTIVE: Helicobacter pylori is the major etiologic agent for chronic active gastritis, and it also plays a crucial role in gastric and duodenal ulcer disease, as well as in gastric carcinoma. H. pylori infection has been shown to decrease plasma somatostatin (SST) and increase plasma gastrin concentrations. Ghrelin is a recently discovered peptide produced mostly in the stomach of rodents and humans and is secreted into the bloodstream. There is no data in the literature about the relationship between H. pylori and ghrelin. DESIGN: Thirty-nine age- and BMI-matched H. pylori infection positive and negative women, from whom biopsy specimens were taken during gastric endoscopy, were included in the study. METHODS: Total ghrelin was measured by enzyme immunoassay (EIA) in Medistek. All samples were measured in duplicate and averaged; results differing by more than 20% were re-assayed. Two biopsy specimens from antrum, corpus and fundus were obtained. RESULTS: Fifteen of the subjects were H. pylori negative and 24 were H. pylori positive. Age, BMI, lipid profile and insulin sensitivity indices of the groups were similar. Plasma ghrelin levels (375.92+/-7.10 vs 370.00+/-4.14 pmol/l; P>0.05) of H. pylori negative and positive groups did not differ significantly. CONCLUSION: H. pylori has no effect on plasma ghrelin concentration.
This article has been cited by other articles:
|
|
 |
|
  J. Roper, F. Francois, P. L. Shue, M. S. Mourad, Z. Pei, A. Z. Olivares de Perez, G. I. Perez-Perez, C.-H. Tseng, and M. J. Blaser Leptin and Ghrelin in Relation to Helicobacter pylori Status in Adult Males J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2350 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pacifico, C. Anania, J. F Osborn, E. Ferrara, E. Schiavo, M. Bonamico, and C. Chiesa Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children Eur. J. Endocrinol., March 1, 2008; 158(3): 323 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T L Peeters Ghrelin: a new player in the control of gastrointestinal functions Gut, November 1, 2005; 54(11): 1638 - 1649. [Full Text] [PDF]
|
|
|
|
 |
|
 M.-S. Wu, W.-J. Lee, H.-H. Wang, S.-P. Huang, and J.-T. Lin A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan Arch Intern Med, July 11, 2005; 165(13): 1552 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Osawa, M. Nakazato, Y. Date, H. Kita, H. Ohnishi, H. Ueno, T. Shiiya, K. Satoh, Y. Ishino, and K. Sugano Impaired Production of Gastric Ghrelin in Chronic Gastritis Associated with Helicobacter pylori J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 10 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Suzuki, T Masaoka, H Hosoda, T Ota, Y Minegishi, S Nomura, K Kangawa, and H Ishii Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils Gut, February 1, 2004; 53(2): 187 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C D R Murray, A V Emmanuel, C U Nwokolo, and H Randeva Ghrelin and Helicobacter pylori * Authors' reply Gut, February 1, 2004; 53(2): 315 - 315. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
