Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women

Division of Endocrinology and Metabolism, Otaru City General Hospital, Otaru, Japan. miyamatsuba@proof.ocn.ne.jp

BACKGROUND: Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of the adipose most-abundant gene transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects. OBJECTIVE: To characterize the relationship between adiponectin and leptin, the ob gene product, in normal-weight and obese women. DESIGN AND METHODS: In this cross-sectional study, we measured fasting plasma adiponectin by ELISA, leptin concentrations by RIA, and related parameters such as blood pressure, body mass index (BMI), body fat mass, lipids, fasting blood glucose and insulin in 353 non-diabetic adult women with a wide range of BMI values. RESULTS: Plasma adiponectin concentrations in women with the highest tertile of BMI (at least 25.0 kg/m(2)) were decreased compared with those in the middle (22.0-25.0 kg/m(2)) or lowest (

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