Eur J Endocrinol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

DOI: 10.1530/eje.0.1400180
European Journal of Endocrinology, Vol 140, Issue 2, 180-185
Copyright © 1999 by European Society of Endocrinology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Echwald, S.
Right arrow Articles by Borch-Johnsen, K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Echwald, S.
Right arrow Articles by Borch-Johnsen, K
Articles

Analysis of the relationship between fasting serum leptin levels and estimates of beta-cell function and insulin sensitivity in a population sample of 380 healthy young Caucasians

SM Echwald, JO Clausen, T Hansen, SA Urhammer, L Hansen, B Dinesen, and K Borch-Johnsen

Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark.

OBJECTIVE: Circulating leptin levels correlate positively with the degree of obesity and prolonged hyperinsulinaemia increases serum leptin levels. Moreover, insulin secreting beta-cells express functional leptin receptors indicating a functional relationship between leptin and insulin. The aim of this study was to examine the relationship between fasting serum leptin levels and measures of insulin sensitivity and beta-cell function in a population-based sample of 380 young healthy Caucasians. DESIGN AND METHODS: Multiple regression analysis was employed to analyse the relationship between fasting serum leptin levels and levels of fasting serum insulin, insulin sensitivity index and acute insulin response (AIR) in a population-based study of 380 young healthy Caucasians who underwent a combined intravenous glucose and tolbutamide tolerance test. RESULTS AND CONCLUSION: Serum leptin levels were positively correlated to measures of adiposity and were 3.2 times higher in women than in men (P<0.00001). In multiple regression analyses adjusting for age, percentage body fat, waist circumference and maximal aerobic capacity, a significant positive correlation was observed between the fasting serum leptin concentrations and both fasting serum insulin levels (P<0.0001) and AIR (P = 0.014) for women. No significant interrelation of these variables was found in men. However, for both genders a significant negative correlation was observed between fasting serum leptin levels and measures of insulin sensitivity index (P = 0.007).


This article has been cited by other articles:


Home page
 DiabetesHome page
C. H. Andreasen, K. L. Stender-Petersen, M. S. Mogensen, S. S. Torekov, L. Wegner, G. Andersen, A. L. Nielsen, A. Albrechtsen, K. Borch-Johnsen, S. S. Rasmussen, et al.
Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation
Diabetes, January 1, 2008; 57(1): 95 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. E Ruhl, J. E Everhart, J. Ding, B. H Goodpaster, A. M Kanaya, E. M Simonsick, F. A Tylavsky, and T. B Harris
Serum leptin concentrations and body adipose measures in older black and white adults
Am. J. Clinical Nutrition, September 1, 2004; 80(3): 576 - 583.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. E Ruhl and J. E Everhart
Leptin concentrations in the United States: relations with demographic and anthropometric measures
Am. J. Clinical Nutrition, September 1, 2001; 74(3): 295 - 301.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 European Society of Endocrinology.