Eur J Endocrinol
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DOI: 10.1530/eje.0.1380070
European Journal of Endocrinology, Vol 138, Issue 1, 70-75
Copyright © 1998 by European Society of Endocrinology
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Articles

Leptin concentrations in serum from a randomly recruited sample of 50- to 80-year-old men and women: positive association with plasma insulin-like growth factors (IGFs) and IGF-binding protein-3 in lean, but not in obese, individuals

T Seck, P Englaro, WF Blum, C Scheidt-Nave, W Rascher, R Ziegler, and J Pfeilschifter

Department of Internal Medicine I, University of Heidelberg, Germany.

OBJECTIVE: The GH/IGF axis is thought to play an important role in the regulation of body composition throughout life. Changes in body fat stores also affect the activity of the GH/IGF axis, but the mechanisms whereby body fat status is signaled to the GH/IGF axis are poorly understood. The newly discovered protein leptin is exclusively produced by adipocytes, and circulating concentrations of leptin closely reflect body fat stores. DESIGN: We here examined whether leptin might be associated with the activity of the GH/IGF axis in a population-based sample. PATIENTS AND METHODS: Circulating concentrations of leptin, IGF-I, IGF-II, and insulin-like growth factor-binding protein-3 (IGFBP-3) were measured in a population-based sample of 50- to 80-year-old men (n=217) and women (n=198) by specific RIA. RESULTS: All three IGF components were significantly positively correlated with leptin in lean women (body mass index (BMI) <25 kg/m2). IGF-II was also positively correlated with leptin in lean men, and positive correlation of leptin with IGF-I in lean men was of borderline statistical significance. In contrast, no correlation was observed in moderately overweight (BMI 25-30kg/m2) and obese individuals (BMI >30 kg/m2). CONCLUSION: Our study shows that serum leptin concentrations are significantly associated with circulating IGF components in lean elderly subjects. The precise mechanism of this interaction between leptin and the GH/IGF system remains to be determined.


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