HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by del Rio, C. G. Articles by Vargas, F. Search for Related Content PubMed Articles by del Rio, C. G. Articles by Vargas, F.

Role of the renin-angiotensin system in the development of thyroxine-induced hypertension

Objective: We evaluated the influence of chronic blockade of the renin-angiotensin system on hypertension induced by long-term thyroxine (T₄) administration. To this end, we determined the effects of chronic treatment with captopril on blood pressure, cardiac hypertrophy and other renal and metabolic variables of hypertensive hyperthyroid rats.

Methods: T₄ was administered s.c. at 0·38 µmol/kg per day and captopril was given in the drinking water (1·38 mmol/l). Both treatments were maintained for 6 weeks. Control rats received tap water. After the treatment period, the rats were placed in metabolic cages. Later, blood pressure was measured in conscious rats by intra-arterial determination.

Results: T₄-treated rats showed an increased mean arterial pressure (MAP) whereas, in rats treated with T₄ plus captopril, MAP was similar to that of the control group. Captopril did not affect the increased heart rate or ventricular weight/body weight ratio of hyperthyroid rats, but it improved the reduced creatinine clearance of these animals.

Conclusions: The elevation in blood pressure produced by long-term T₄ administration was prevented by chronic blockade of the renin-angiotensin system. Captopril improved the renal function of hyperthyroid rats, but did not affect the relative cardiac hypertrophy of these animals.

European Journal of Endocrinology 136 656–660

This article has been cited by other articles:

				J. M. Moreno, I. Rodriguez Gomez, R. Wangensteen, M. Alvarez-Guerra, J. d. D. Luna, J. Garcia-Estan, and F. Vargas Tempol improves renal hemodynamics and pressure natriuresis in hyperthyroid rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R867 - R873. [Abstract] [Full Text] [PDF]

				F. Vargas, J. M. Moreno, R. Wangensteen, I. Rodriguez-Gomez, and J. Garcia-Estan The endocrine system in chronic nitric oxide deficiency Eur. J. Endocrinol., January 1, 2007; 156(1): 1 - 12. [Abstract] [Full Text] [PDF]

				R. Wangensteen, I. Rodriguez-Gomez, J. M. Moreno, M. Alvarez-Guerra, A. Osuna, and F. Vargas Effects of chronic treatment with 7-nitroindazole in hyperthyroid rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1376 - R1382. [Abstract] [Full Text] [PDF]

				F. Vargas, J. M. Moreno, I. Rodriguez-Gomez, R. Wangensteen, A. Osuna, M. Alvarez-Guerra, and J. Garcia-Estan Vascular and renal function in experimental thyroid disorders Eur. J. Endocrinol., February 1, 2006; 154(2): 197 - 212. [Abstract] [Full Text] [PDF]

				I. Rodriguez-Gomez, R. Wangensteen, J. M. Moreno, V. Chamorro, A. Osuna, and F. Vargas Effects of chronic inhibition of inducible nitric oxide synthase in hyperthyroid rats Am J Physiol Endocrinol Metab, June 1, 2005; 288(6): E1252 - E1257. [Abstract] [Full Text] [PDF]

				I. Rodriguez-Gomez, J. Sainz, R. Wangensteen, J. M. Moreno, J. Duarte, A. Osuna, and F. Vargas Increased Pressor Sensitivity to Chronic Nitric Oxide Deficiency in Hyperthyroid Rats Hypertension, August 1, 2003; 42(2): 220 - 225. [Abstract] [Full Text] [PDF]