| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The present study was performed to examine the effect of natural menopause on serum levels of IGF-I, IGF-binding protein (IGFBP-2) and -3 as well as on bone mass and lipid metabolism in perimenopausal women. One hundred and twenty-one healthy Japanese women, who were 45–55 years old, were studied (71 premenopausal and 50 postmenopausal women 1–9 years after menopause). Bone mineral density (BMD) was measured at the middle third of the radius by using dual energy X-ray absorptiometry. Serum levels of IGF-I, but not those of IGFBP-2 or -3, were significantly reduced in the postmenopausal group compared with the premenopausal group. One year after menopause, serum IGF-I levels were significantly lower, and the biochemical markers of bone turnover, such as serum total alkaline phosphatase level and urinary calcium to creatinine ratio, were significantly higher than the premenopausal levels. Serum levels of IGF-I, but not those of IGFBP-2 or-3, were positively correlated with BMD. Serum levels of IGFBP-2, but not those of IGF-I or IGFBP-3, were negatively correlated with body mass index and body weight. Finally, serum levels of IGFBP-3, but not those of IGF-I, were positively correlated with serum levels of total cholesterol and triglyceride. The present findings suggest that a rapid decrease in serum IGF-I levels after menopause might be partly involved in bone loss following gonadal failure and that IGFBP-2 and -3 might be related to the regulation of body mass and lipid metabolism during perimenopause respectively, although the mechanisms remain unknown.
European Journal of Endocrinology 136 608–616
This article has been cited by other articles:
|
|
 |
|
  T. Ueland GH/IGF-I and bone resorption in vivo and in vitro Eur. J. Endocrinol., March 1, 2005; 152(3): 327 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Arjmandi, D. A. Khalil, B. J. Smith, E. A. Lucas, S. Juma, M. E. Payton, and R. A. Wild Soy Protein Has a Greater Effect on Bone in Postmenopausal Women Not on Hormone Replacement Therapy, as Evidenced by Reducing Bone Resorption and Urinary Calcium Excretion J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1048 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Boyd, L. Martin, J. Stone, L. Little, S. Minkin, and M. Yaffe A Longitudinal Study of the Effects of Menopause on Mammographic Features Cancer Epidemiol. Biomarkers Prev., October 1, 2002; 11(10): 1048 - 1053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Khalil, E. A. Lucas, S. Juma, B. J. Smith, M. E. Payton, and B. H. Arjmandi Soy Protein Supplementation Increases Serum Insulin-Like Growth Factor-I in Young and Old Men but Does Not Affect Markers of Bone Metabolism J. Nutr., September 1, 2002; 132(9): 2605 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Sibling Pair Linkage and Association Studies between Bone Mineral Density and the Insulin-Like Growth Factor I Gene Locus J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4467 - 4471. [Abstract] [Full Text]
|
|
|
|
|
|
P. Vestergaard, A. P. Hermann, H. Ørskov, and L. Mosekilde Effect of Sex Hormone Replacement on the Insulin-Like Growth Factor System and Bone Mineral: A Cross-Sectional and Longitudinal Study in 595 Perimenopausal Women Participating in the Danish Osteoporosis Prevention Study J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2286 - 2290. [Abstract] [Full Text]
|
|
|
|
|
|
T. Seck, B. Scheppach, S. Scharla, I. Diel, W. F. Blum, H. Bismar, G. Schmid, B. Krempien, R. Ziegler, and J. Pfeilschifter Concentration of Insulin-Like Growth Factor (IGF)-I and -II in Iliac Crest Bone Matrix from Pre- and Postmenopausal Women: Relationship to Age, Menopause, Bone Turnover, Bone Volume, and Circulating IGFs J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2331 - 2337. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
