HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nyholm, B. Articles by Schmitz, O. Search for Related Content PubMed Articles by Nyholm, B. Articles by Schmitz, O.

Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus

Objective: To explore a possible association between serum concentration of leptin, insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM).

Design: Forty first-degree relatives of NIDDM patients and 35 control subjects matched for age, gender and body mass index underwent a hyperinsulinaemic (insulin infusion rate 0·6 mU/kg per min) euglycaemic clamp combined with indirect calorimetry. Serum leptin was measured in fasting blood samples obtained before the clamp.

Results: All subjects had a normal oral glucose tolerance test. Insulin-stimulated glucose uptake (M) was decreased in the relatives compared with the control subjects (4·58 ± 0·27 versus 606 ± 0·25 mg/kg per min, P < 0·001). Conversely, serum leptin was increased in the relatives (9·6·/÷ 1·1 versus 6·1·/÷ 1·2 ng/ml (geometric mean·/÷ antilog S.E.M.). P < 0·05). A positive correlation was observed between circulating levels of leptin and percentage body fat (P < 0·001) and inverse correlations were found between leptin, M (P < 0·01), maximal aerobic capacity (VO₂ max) (P < 0·01), and energy expenditure (P 0·01) in both groups. In multiple linear regression analysis, percentage body fat, gender and M significantly determined the level of leptin (r² = 0·71, P < 0·001) whereas family history of NIDDM and VO₂ max did not.

Conclusion: Serum leptin is increased in insulin-resistant offspring of NIDDM patients. The association between leptin, anthropometric measures and insulin sensitivity is, however, comparable with that of a control group. The increased concentrations of serum leptin in the relatives appear to be associated with the insulin resistance, but not with a family history of NIDDM.

European Journal of Endocrinology 136 173–179

This article has been cited by other articles:

				A. S. Rossi, Y. B. Lombardo, J.-M. Lacorte, A. G. Chicco, C. Rouault, G. Slama, and S. W. Rizkalla Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R486 - R494. [Abstract] [Full Text] [PDF]

				F. Maingrette and G. Renier Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C Diabetes, August 1, 2003; 52(8): 2121 - 2128. [Abstract] [Full Text] [PDF]

				E. Peyron-Caso, M. Taverna, M. Guerre-Millo, A. Veronese, N. Pacher, G. Slama, and S. W. Rizkalla Dietary (n-3) Polyunsaturated Fatty Acids Up-Regulate Plasma Leptin in Insulin-Resistant Rats J. Nutr., August 1, 2002; 132(8): 2235 - 2240. [Abstract] [Full Text] [PDF]

				J. R. Levy, B. Davenport, J. N. Clore, and W. Stevens Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E626 - E633. [Abstract] [Full Text] [PDF]

				M. Ozata, D. Gungor, M. Turan, G. Ozisik, N. Bingol, T. Ozgurtas, and I. C. Ozdemir Improved Glycemic Control Increases Fasting Plasma Acylation-Stimulating Protein and Decreases Leptin Concentrations in Type II Diabetic Subjects J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3659 - 3664. [Abstract] [Full Text] [PDF]

				M. Blüher, J. Kratzsch, and R. Paschke Plasma Levels of Tumor Necrosis Factor-{alpha}, Angiotensin II, Growth Hormone, and IGF-I Are Not Elevated in Insulin-Resistant Obese Individuals With Impaired Glucose Tolerance Diabetes Care, February 1, 2001; 24(2): 328 - 334. [Abstract] [Full Text]

				S.-i. Yamagishi, D. Edelstein, X.-l. Du, Y. Kaneda, M. Guzman, and M. Brownlee Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A J. Biol. Chem., June 29, 2001; 276(27): 25096 - 25100. [Abstract] [Full Text] [PDF]