HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Panno, M. Articles by Andò, S Search for Related Content PubMed Articles by Panno, M. Articles by Andò, S

Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells

Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, Pezzi V, Palmero S. Fugassa E, Andò S. Effect of triiodothyronine administration on estrogen receptor contents in peripuberal Sertoli cells. Eur J Endocrinol 1996:134:633–8. ISSN 0804–4643

The effects of thyroid hormone on androgen metabolism in peripuberal Sertoli cells through the inhibition of estradiol production have been reported previously. It was our intention to investigate further the possible role of thyroid hormone on the interaction between testicular steroids and Sertoli cells by analyzing the effects of triiodothyronine (T₃) on estrogen receptor content in 2-, 3- and 4week-old euthyroid rats. Triiodothyronine treatment (3 µg/100 body wt per day) given during the last week prior to sacrifice resulted in reduced testicular growth in 2-week-old animals. Sertoli cells from all groups were cultured initially under basal conditions for the first 24 h and subsequently in the presence of testosterone and/or T₃ for the additional 24 h. The in vitro addition of T₃ induced a decrease of estrogen receptors (ERs) in 2- and 3-week-old animals that appeared more pronounced especially in the presence of T₃ and testosterone. When T₃ was tested in vivo we noticed that the decrease of ER content was even greater in all three groups under the in vitro influence of both T₃ and testosterone. In 3-week-old animals a simultaneous assay of ERs in both nuclear and cytoplasmic compartments was performed. The ER concentrations in the nucleus were closely related to those of the cytoplasm. The in vivo administration of T₃ was responsible for a greater decrease of ERs in the nucleus than in the cytosol. On the basis of these results, and in agreement with our previous data, we speculate that the effect of T₃ in the maturational events of Sertoli cells could involve both estradiol production and ER content.

Sebastiano Andò Cattedra di Fisiopatologia Endocrina, Dipartimento di Biologia Cellulare, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy

This article has been cited by other articles:

				M. A. Siddiqi, R. H. Laessig, and K. D. Reed Polybrominated Diphenyl Ethers (PBDEs): New Pollutants-Old Diseases Clin. Med. Res., October 1, 2003; 1(4): 281 - 290. [Abstract] [Full Text] [PDF]

				S. Catalano, V. Pezzi, A. Chimento, C. Giordano, A. Carpino, M. Young, M. J. McPhaul, and S. Ando Triiodothyronine Decreases the Activity of the Proximal Promoter (PII) of the Aromatase Gene in the Mouse Sertoli Cell Line, TM4 Mol. Endocrinol., May 1, 2003; 17(5): 923 - 934. [Abstract] [Full Text] [PDF]

				A. M. M. van Pelt, D. G. de Rooij, B. van der Burg, P. T. van der Saag, J.-A. Gustafsson, and G. G. J. M. Kuiper Ontogeny of Estrogen Receptor-{beta} Expression in Rat Testis Endocrinology, January 1, 1999; 140(1): 478 - 483. [Abstract] [Full Text]

				E. Leibenluft, P. J. Schmidt, E. H. Turner, M. A. Danaceau, S. B. Ashman, T. A. Wehr, and D. R. Rubinow Effects of Leuprolide-Induced Hypogonadism and Testosterone Replacement on Sleep, Melatonin, and Prolactin Secretion in Men J. Clin. Endocrinol. Metab., October 1, 1997; 82(10): 3203 - 3207. [Abstract] [Full Text] [PDF]