HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hanew, K. Articles by Abe, K. Search for Related Content PubMed Articles by Hanew, K. Articles by Abe, K.

Plasma GH responses to human GHRH-antagonist in normal subjects

Hanew K, Tanaka A, Utsumi A, Sugawara A, Abe K, Plasma GH responses to human GHRH-antagonist in normal subjects. Eur J Endocrinol 1996;134:67–72. ISSN 0804–4643

The effect of GHRH-antagonist {N-Ac-Tyr¹, D-Arg²) GRF-(1–29)-NH₂} on plasma GH morning and evening secretion was evaluated in 14 normal subjects (10 males, 4 females, aged 19–25 years). Plasma GH was determined using a high sensitivity IRMA kit (detection limit, 0.006 µg/l). After intravenous infusion of GHRH-antagonist (100 µg/100 ml saline over 75 min) in the morning, plasma GH remained constant during the 150 min post-infusion (N = 6). In contrast, when GHRH-antagonist was administered in the evening, plasma GH showed a clear and gradual decrease through the initial 90 min and returned to baseline levels at 150 min. Plasma GH values were also significantly lower from 75 min to 135 min when compared to physiological fluctuations in plasma GH (P < 0.05). Other anterior pituitary hormones remained unaffected by GHRH-antagonist. In conclusion, our data suggest that evening basal GH secretion, but not morning GH secretion, is maintained by endogenous GHRH.

K Hanew, The Second Department of Internal Medicine, Tohoku University School of Medicine. 1-1 Seiryocho, Sendai 980, Japan