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Anti-prolactin autoantibodies and hyperprolactinaemia

Recent reports by Hattori et al. (1, 2) provide evidence for immunoglobulin binders of prolactin, i.e. anti-prolactin autoantibodies, as a cause of hyperprolactinaemia. Specific assays for rapid identification of anti-prolactin autoantibodies are currently unavailable, but the polyethylene glycol (PEG) precipitation screening test combined with measurement of free prolactin as detailed by Hattori et al. (1, 2) has been proposed as a first-line evaluation of suspected cases of anti-prolactin autoantibody-induced hyperprolactinaemia (3). It has also been proposed that laboratories providing a prolactin assay service may be required to offer routine anti-prolactin autoantibody measurements (3).

We screened 86 serum samples in duplicate for anti-prolactin autoantibodies using the PEG precipitation method. The samples were selected from among those received in our laboratory for routine measurement of prolactin. Fifty-one of these sera had elevated prolactin concentrations (> 420 mU/l; range 434–17 000) while 35 had normal concentrations. For the PEG screening test, 100 µl

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