Eur J Endocrinol
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DOI: 10.1530/eje.0.1330071
European Journal of Endocrinology, Vol 133, Issue 1, 71-74
Copyright © 1995 by European Society of Endocrinology
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Circadian thyrotropin variations are preserved in normal pregnant women

Elio Roti, Luigi Bartalena, Roberta Minelli, Mario Salvi, Eliana Gardini, Antonio Pistolesi, Enio Martino and Lewis E Braverman

Roti E, Bartalena L, Minelli R, Salvi M, Gardini E, Pistolesi A, Martino E, Braverman LE. Circadian thyrotropin variations are preserved in normal pregnant women. Eur J Endocrinol 1995;133:71–4. ISSN 0804–4643

Serum thyrotropin (TSH) concentration circadian rhythm is abolished in many endocrine and nonendocrine diseases. In the present study we have measured serum TSH concentration over 24 h every 2 h in second and third trimester pregnant women. During the 24-h period, serum free thyroxine and free triiodothyronine concentrations did not change significantly. In contrast, serum TSH concentrations demonstrated significant circadian variations both in the second and third trimester pregnant women (p<0.02 and p <0.005, respectively). In summary, second and third trimester pregnancy is associated with a normal circadian TSH rhythm.

Elio Roti, Centro per lo Studio, Prevenzione, Diagnosi e Cura delle Tireopatie, University of Parma, via Gramsci 14, 1-43100 Parma, Italy







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