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Effect of liver damage on the pharmacokinetics of dexamethasone

Kütemeyer S, Schürmeyer TH, von zur Mühlen A. Effect of liver damage on the pharmacokinetics of dexamethasone. Eur J Endocrinol 1994;131:594–7. ISSN 0804–4643

By measuring the pharmacokinetics of dexamethasone in 48 patients with various degrees of disturbances in liver function, we could demonstrate a decrease in the metabolic clearance of this steroid by 53% if the activity of the plasma cholinesterase was lowered to less than 2 kU/l. Results suggest that the dosage of dexamethasone given for diagnostic or therapeutic purpose needs to be adjusted in such patients.

TH Schürmeyer, Abteilung klinische Endokrinologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D-30625 Hannover, Germany

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